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KMID : 1123920060200020410
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 2 p.410 ~ p.413
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Protective Effects of Iljungbogan-Tang on Acute Hepatotoxicity Induced by and Acetaminophen
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Kim Joon-Myoung
Park Yang-Chun
Son Gi-Jung
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Abstract
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This study was done to investigate the protective effects of Iljungbogan-Tang on acute hepatotoxicity of rats induced by and acetaminophen. The subject animals were divided into 3 groups : control group(administrated 0.5% carboxymethyl cellulose), sample group(30, 100, 300, 600mg/kg administrated), positive control group (administrated silymarine), Acute hepatotoxicity of rats were induced by and acetaminophen, and the serum transaminase(AST, ALT) were measured for enzyme activities. The inhibitory effects on the serum AST activities were noted in sample group(100, 300, 600mg/kg administrated) on hepatotoxicity of rats induced by . The inhibitory effects on the serum AST, ALT activities were noted in sample group(30mg/kg administrated) on hepatotoxicity of rats induced by acetaminophen. The inhibitory effects on the serum AST activities were noted in sample group(600mg/kg single dose administrated) on hepatotoxicity of rats induced by acetaminophen. It is considered that Iljungbogan-Tang has protective effects against hepatotoxicity in rats induced by and acetaminophen. So it is required to study about the actions of mutual relation of medicines and patho-mechanism through experiment.
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KEYWORD
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Iljungbogan-Tang, hepatotoxicity, acetaminophen
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